Nicotinamide Adenine Dinucleotide or NAD plays a central role in metabolism and is a key molecule for health and longevity. NAD exist in four forms (NAD+, NADH, NADP+, NADPH), each vital for energy metabolism and life.
NADs are indicators of health and longevity
NAD is needed to activate Sirtuins, a family of enzymes that regulate longevity in mammals. NAD levels can be increased with NAD boosters such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN).
Assess the required dose of NAD-boosters and track levels of NADs after intervention
NAD measurement can be used to monitor metabolic health and to generate data from clinical trials and basic research.
We developed a conventional analysis method for NAD metabolites in biological samples including blood. The goal is to develop and validate the test for clinical chemistry laboratories.
A future clinical NAD test
1) enables to screen for individuals with treatable NAD deficiency
2) serves as guideline for treatment with NAD booster
3) enables to monitor supplementation efficacy and dose adjustment
NADMED is the first cost-effective and accurate test for NAD metabolites in human blood. The method is applicable for any standard laboratory, and easily scalable to even the largest of clinical trials or cohort studies as well as clinical labs.
One step extraction from blood and optimized assays for
NADH, NAD+, NADPH, NADP+,
ideal for clinical chemistry labs.
NADMED assay is concordant with MS allowing the study of reduced and oxidized forms also in blood.
Works from blood and other tissues
e.g. extracted cells, brain, liver, muscle.
Solidify your preclinical and clinical biomarker and CDx strategy with accurate and robust NAD assays
Co-development and license opportunities for In Vitro Diagnostic testing
Fuel discovery and generate epidemiological evidence with high-throughput profiling of NAD metabolites